Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks
نویسندگان
چکیده
منابع مشابه
Organising metabolic networks: Cycles in flux distributions.
Metabolic networks are among the most widely studied biological systems. The topology and interconnections of metabolic reactions have been well described for many species. This is, however, not sufficient to understand how their activity is regulated in living organisms. These descriptions depict a static set of possible chains of reactions, with no information about the dynamic activity of re...
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MOTIVATION Elementary flux mode (EFM) is a fundamental concept as well as a useful tool in metabolic pathway analysis. One important role of EFMs is that every flux distribution can be decomposed into a set of EFMs and a number of methods to study flux distributions originated from it. Yet finding such decompositions requires the complete set of EFMs, which is intractable in genome-scale metabo...
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The dynamic behaviour of metabolic networks is determined by the kinetic properties and the cellular levels of the enzymes and transporters involved. Changes in the concentrations of enzymes can be assessed by proteomics measurements or – more indirectly – by gene expression analyses. However, a straightforward interpretation of such data with respect to metabolic functions of the cell is diffi...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2007
ISSN: 1752-0509
DOI: 10.1186/1752-0509-1-23